The Premium Surgiclip™ III clip applier consists of an applier shaft with attached handles and integrated cartridge containing 20 titanium clips. The clip applier jaw is placed around a vessel or other tubular structure. As the handles of the applier are brought together, the clip is closed around the vessel or structure. The device contains a ratchet mechanism to ensure that a clip is not allowed to release until a full handle squeeze is applied. As the handles are released, a new clip is automatically loaded into the clip applier jaw. After the last clip is used, the device is designed to lockout which prevents the handles from being closed.